010-80117836
276385203@qq.com |
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| Claudin-2 Mouse mAb(8H11) |
| Claudin2,CLDN2,SP82 |
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| Cat#： TDY766 | Source： Mouse | Type： Monoclonal | |
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| Applications: WB,IHC |
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Reactivity: H,R,M |
| MW.(KDa): 25 |
Isotype: IgG1 |
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Applications: WB-Western blot IHC-Immunochemistry IF-Immunofluorescence IP-Immunoprecipitation ChIP-Chormatin Immunoprecipitation
Reactivity: H-Human R-Rat M-Mouse Mk-Monkey Dg-Dog Ch-Chicken Hm-Hamster Rb-Rabbit Sh-Sheep Pg-Pig
The claudin family is composed of 23 integral membrane proteins, and their expression, which varies among tissue types, may determine both the strength and properties of the epithelial barrier. Alteration in claudin protein expression pattern is associated with several types of cancer . Claudin-2 is expressed primarily in the proximal tubule of the normal mammalian kidney, where it regulates transepithelial ion (e.g., Na+, Cl-) reabsorption . Increased expression of Claudin-2 has been reported in some cancer cell lines , including A549 lung adenocarcinoma cells, where its nuclear distribution was positively associated with enhanced proliferation .
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| Western Blot |
Western blot analysis of 1) Hela Cell Lysate, 2) Mouse Heart Tissue Lysate , 3) Rat Heart Tissue Lysate using Claudin-2 （TDY766）Mouse mAb diluted at 1:2000.
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| IHC |
Immunohistochemical analysis of paraffin-embedded Human Kidney Carcinoma Tissue using Claudin-2 （TDY766）Mouse mAb diluted at 1:200.
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| IHC |
Immunohistochemical analysis of paraffin-embedded Human Endometrial Carcinoma Tissue using Claudin-2 （TDY766）Mouse mAb diluted at 1:200.
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| Source |
Mouse monoclonal antibody is prepared by immunizing synthetic peptide coupled to KLH.
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| Specificity |
The Claudin-2 mouse monoclonal antibody can detect endogenous Claudin-2 proteins.
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| Storage |
Store at -20°C. Stable for one year from the date of shipment.
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| Concentration |
1mg/ml in PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol.
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| Dilutions |
WB 1:1,000-2,000 IHC:1;100-1:200
(Optimal dilutions should be determined by the end user)
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| Size: |
TDY766C-50μL ￥1000
TDY766F-100μL ￥1800 |
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| New Product: |
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